GW27-e0956 Hepatocyte growth factor-mediated induction of stromal-derived factor 1α (SDF-1α) contributes to hypoxia-driven vascular remodelling and vasoconstriction
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چکیده
منابع مشابه
HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction.
AIMS Hypoxic conditions stimulate pulmonary vasoconstriction and vascular remodelling, both pathognomonic changes in pulmonary arterial hypertension (PAH). The secreted protein thrombospondin-1 (TSP1) is involved in the maintenance of lung homeostasis. New work identified a role for TSP1 in promoting PAH. Nonetheless, it is largely unknown how hypoxia regulates TSP1 in the lung and whether this...
متن کاملCorrigendum to: HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction
doi:10.1093/cvr/cvw251 ......................................................................................................................................................................... Corrigendum to: HIF-2a-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction [Cardiovasc Res 2016; 109 (1): 115–130] The authors of the a...
متن کاملHypoxic stress simultaneously stimulates vascular endothelial growth factor via hypoxia-inducible factor-1α and inhibits stromal cell-derived factor-1 in human endometrial stromal cells.
BACKGROUND Hypoxia of the human endometrium is a physiologic event occurring during the perimenstrual period and the local stimulus for angiogenesis. The aim of this study was to investigate the effects of hypoxic stress on the regulation of vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1 (SDF-1/CXCL12), and the potential role of hypoxia-inducible factor-1α (HIF-1α) ...
متن کاملExpression of vascular endothelial growth factor and hypoxia-inducible factor 1α in rat traumatic lung injury
Hypoxia-inducible factor 1α (HIF-1α) is an important transcription factor in mediating oxygen homeostasis that can regulate vascular endothelial growth factor (VEGF) gene transcription. HIF-1α can induce neovascularization in ischemic injury. This research observed HIF-1α and VEGF expression in traumatic lung injury (TLI) to discuss their correlation. Healthy male SD rats at 7-week old were ran...
متن کاملCXCR7 Silencing Attenuates Cell Adaptive Response to Stromal Cell Derived Factor 1α after Hypoxia
Previous studies have shown that chemotactic factor stromal-cell derived factor 1α (SDF1α) promotes cell recovery from hypoxic injury via its main receptor C-X-C chemokine receptor type (CXCR) 4. However, the role of its new receptor CXCR7 on cell repair against hypoxia and cell response to SDF1α remains largely unknown. In this study, neurons induced from hippocampal progenitor cells were pre-...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2016
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2016.07.124